美国与俄罗斯签署贸易协定的当晚,一位重要人物被刺杀,而特种部队狙击手布兰登•贝克特(查德•科林斯 Chad Michael Collins 饰)则被当成了头号嫌疑人。死里逃生后,布兰登意识到此事可能牵扯到了政府内部的黑暗阴谋,于是便找到了他唯一能信任的伙伴—他的父亲,“ 双狙人”托马斯•贝克特(汤姆•贝伦杰 Tom Berenger 饰)。父子二人再度联手,而这一次,他们不仅要面对中情局、俄罗斯雇佣兵的追捕,更要面对一位人称“死亡小姐”的日本极道杀手(秋元才加 Sayaka Akimoto 饰),而她拥有着足以与二位传奇狙击手相匹敌的狙击技能......
本片为“双狙人”系列的第八部作品。
Sometime in the near future, paraplegic prison inmate Matt Mills meets The Board of Satoshi-Telefair Industries, who thank him for joining the Program. Under pressure and with a promise to make him walk again, Mills agrees to volunteer. He is injected with a synthetic nanomaterial and suffocated, only to wake up with restored use of his legs, yet alone in a steel cell in the first spoke of an experimental apparatus - The Wheel. A series of assailants inflict a multitude of damage to Mills' body and torment his mind, yet the synthetic nanomaterial not only restores his damaged organs, it re-engineers his strength. The experiment might be designed to kill, but Mills is determined to survive - and get back to his daughter before The Board finds her first.