黑帮老大艾迪?金策划了一起凶杀案，被偶然路过的年轻人西恩?琼斯（Nathan Phillips 饰）目击。为了在法庭上成功指控这个作恶多端的黑社会头子，警方派出资深联邦密探尼维利?费恩（Samuel L. Jackson 饰）负责保护西恩，并将其从夏威夷护送至洛杉矶法庭。为避免证人遇害，尼维利采取声东击西的策略，与西恩偷偷乘上一架普通的红眼航班。
然而这项绝密的计划被艾迪安排在警方的内奸获知，为了逃脱法律制裁，艾迪派出携带大量毒蛇的杀手登上飞机，一场离奇恐怖的血腥灭口案件就此展开……
In “Muzzle City of Wolves,” Jake Rosser (Eckhart), haunted by PTSD from his days as a K-9 officer, endeavors to lead a peaceful life with his family and retired K-9 companion, Socks. But the tranquility quickly dissolves when a ruthless gang targets them in a brutal attack. Determined to protect his loved ones, Jake and his new K-9 partner Argos delve into a violent underbelly...
In an alternate present, genetically enhanced humans dominate society. Outcasts Leon and Chloe fight for justice against corrupt politicians exploiting genetic disparity, risking everything to challenge the oppressive system.
